TB-500
10 mg
Synthetic fragment of Thymosin Beta-4 studied for actin regulation and tissue repair.
Overview
TB-500 is a synthetic peptide fragment derived from Thymosin Beta-4 (Tβ4), a naturally occurring protein involved in cell migration, differentiation, and tissue regeneration. It is one of the most studied compounds for actin-binding research.
Mechanism of Action
TB-500 binds G-actin, sequestering monomers and regulating actin polymerization dynamics essential to cell motility and angiogenesis. It has been shown in research models to upregulate endothelial cell migration, promote vascular development, and modulate inflammation through interaction with the PINCH-ILK-AKT pathway.
Research Findings
Thymosin β4 and Tissue Repair
Annals NY Acad. Sci., 2012 (PMC3499725)
Reviews Tβ4 fragment activity in cardiac, dermal and corneal repair models.
Actin Sequestration by Tβ4
FEBS Letters, 2014
Molecular characterization of actin-binding behavior.
Potential Research Applications
- Cellular migration studies
- Cardiac repair models
- Wound contraction research
- Anti-inflammatory pathway analysis
Often researched with
BPC-157
10 mg
Pentadecapeptide derived from gastric protein studied for systemic repair pathways.
GHK-Cu
50 mg
Copper-binding tripeptide investigated for skin remodeling and tissue repair pathways.
Wolverine Stack
BPC-157 5 mg + TB-500 5 mg
Combination blend studied for systemic repair pathways.
Thymosin Beta-4
10 mg
Full-length actin-sequestering peptide for repair research.